flomax use in women

[gaba101]

---

Members do not see this ad.

I was working on the troubleshoot one day and came across "flomax" for a lady patient (per first name and per "female" selection in the patient profile)
Why on earth would a woman use flomax? Some possible explanations:

1) She's a transsexual (i guess in such operations they only work on the external genitalia, rather than the internal)

2) there are some individuals where their internal and external genitalia do not match (i.e. female externally but male internally b/c of a prostate...could possibly due to mom touching finasteride when mom was pregnant with her baby girl?)

 

[WVUPharm2007]

I think I recall from biochemistry that the alpha1-A adrenoreceptor had a few other limited functions, too. A quick pubmed search reveals studies that show it having a role in myocardium hypertrophy (in rats, anyway). Though I'm not really sure this means anything as I don't know how clinically useful blocking those receptors would be...or if anybody has actually used it for this purpose before.

Really, I just don't know. Of course your transsexual theory may very well be right, too....

 

[All4MyDaughter]

Flomax causes relaxation of the trigone muscle in the neck of the bladder (via the alpha-1-a receptors). Relaxation of the muscle facilitates the release of urine. This female patient must be having difficulty urinating.

Tamsulosin is an antagonist of alpha1A-adrenoreceptors in the prostate. Smooth muscle tone in the prostate is mediated by alpha1A-adrenoreceptors; blocking them leads to relaxation of smooth muscle in the bladder neck and prostate causing an improvement of urine flow and decreased symptoms of BPH. Approximately 75% of the alpha1-receptors in the prostate are of the alpha1A subtype.

Unlabeled/Investigational use: Symptomatic treatment of bladder outlet obstruction or dysfunction

 

[gaba101]

Tamsulosin is an antagonist of alpha1A-adrenoreceptors in the prostate. Smooth muscle tone in the prostate is mediated by alpha1A-adrenoreceptors; blocking them leads to relaxation of smooth muscle in the bladder neck and prostate causing an improvement of urine flow and decreased symptoms of BPH. Approximately 75% of the alpha1-receptors in the prostate are of the alpha1A subtype.

Unlabeled/Investigational use: Symptomatic treatment of bladder outlet obstruction or dysfunction

As your Lexi says, flomax works on the PROSTATE gland by blocking the alpha1a-adrenoreceptors (in the prostate), which mediate the "Smooth muscle tone in the prostate." "Them" = "alpha1a-adrenoreceptors [of the prostate gland]" in the following sentence-- "blocking them leads to relaxation of smooth muscle in the bladder neck and prostate causing an improvement of urine flow and decreased symptoms of BPH." so without a prostate, flomax doesn't work. So bottom line is that this lady has a prostate gland, no?

 

[npage148]

I've also seen it multiple times to help facilitate passage of a kidney stone in med and women.

 

[BMBiology]

I've also seen it multiple times to help facilitate passage of a kidney stone in med and women.

👍

 

[gaba101]

I've also seen it multiple times to help facilitate passage of a kidney stone in med and women.

Thanks npage148--that's exactly the answer I was looking for.

 

[All4MyDaughter]

As your Lexi says, flomax works on the PROSTATE gland by blocking the alpha1a-adrenoreceptors (in the prostate), which mediate the "Smooth muscle tone in the prostate." "Them" = "alpha1a-adrenoreceptors [of the prostate gland]" in the following sentence-- "blocking them leads to relaxation of smooth muscle in the bladder neck and prostate causing an improvement of urine flow and decreased symptoms of BPH." so without a prostate, flomax doesn't work. So bottom line is that this lady has a prostate gland, no?

No. Those receptors are present in the trigone muscle and the urethra as well. I should have clarified that for you. No prostate is required for Flomax to work, hence it is useful in men and women.

 

[Old Timer]

As far as I remember alpha one receptors are located in the urinary bladder sphincter and blockade of these receptors would result in relaxation of the sphincter and increased urinary flow.

 

[WVUPharm2007]

Eh, urethral relaxation, that's boring. I like my anti-myocardial hypertrophy theory better.

 

[Old Timer]

Eh, urethral relaxation, that's boring. I like my anti-myocardial hypertrophy theory better.

Me too. The only thing I know for sure is the drug has no idea what the approved labeling says. It will hit alpha one receptors wherever they are in the body. Physicians have been using drugs for "unapproved" indications for years.

 

[tussionex]

another vote for kidney stones
we use it in our ER all the time

 

[WVUPharm2007]

Really, God only knows what they are using it for. Rationale for prescribing is so lax and as physicians are getting kookier and kookier, you could say the indication is for brain gnomes and somebody would dispense it.

 

[71263]

Arent alpha-1 blockers also used to treat hypertension?? 😕

 

[WVUPharm2007]

Arent alpha-1 blockers also used to treat hypertension?? 😕

Yeah, but this is a super magical type that are specific for alpha-1 receptors in specific super magical locations. Hence "super magical alpha 1-a inhibitor".

Zpacksux is super magical.

 

[PharmDstudent]

Zpacksux is super magical

and retired.
Get with the program, duh! That John Deer ridin' lawnmower left him stranded across the border somewhere. He was chasing those illegals for not cutting his grass, and now he's part of some mafia's drug ring. Don't send him that Sudafed even if he asks. He already has the nitrogen fertilizer!
(That's just the rumor I heard.)

 

[Epic]

Who is this Zpacksux y'all are speaking of?

 

[PharmDstudent]

Who is this Zpacksux y'all are speaking of?

He's the one that started the dreaded NCAA football thread...

 

[WVUPharm2007]

Well, you know what they said when they created the septic tank. An outhouse by any other name smells just as bad.