USMLE Folks,

[luxor]

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While I am studying USMLE World, I got a question.

"Insufficient NADPH results in an inability to maintain glutathione in the reduced state.
This increases the vulnerability of erythrocytes to oxidative stress and manifests with hemolysis
induced by infection, drug or other oxidants"

The glutathione is an strong antioxidant as you know. Why does inability to maintain glutathione in the reduced state increase the vulnerability of erythrocytes to oxidative stress?
If the glutathione can not be maintained in the reduced state, that means the glutathione is in the high level of antioxidant, then it shouldn't be oxidative stress I think.

 

[JooceMan137]

While I am studying USMLE World, I got a question.

"Insufficient NADPH results in an inability to maintain glutathione in the reduced state.
This increases the vulnerability of erythrocytes to oxidative stress and manifests with hemolysis
induced by infection, drug or other oxidants"

The glutathione is an strong antioxidant as you know. Why does inability to maintain glutathione in the reduced state increase the vulnerability of erythrocytes to oxidative stress?
If the glutathione can not be maintained in the reduced state, that means the glutathione is in the high level of antioxidant, then it shouldn't be oxidative stress I think.

Reduced NADPH is not directly what you want, it's that the NADPH reducing glutathione. Then, the reduced glutathione donates it's hydrogen (essentially an electron) to the oxygen radical to neutralize it.

Insufficient NADPH= insufficient reduced glutathione= reduced ability to neutralize oxygen radicals (Basically oxygen with a lone reactive electron).

 

[luxor]

Thank

Reduced NADPH is not directly what you want, it's that the NADPH reducing glutathione. Then, the reduced glutathione donates it's hydrogen (essentially an electron) to the oxygen radical to neutralize it.

Insufficient NADPH= insufficient reduced glutathione= reduced ability to neutralize oxygen radicals (Basically oxygen with a lone reactive electron).

 

[luxor]

Thank you very much Necrosis. Your answer made my question clear.