The 2 Pyruvate are 3 carbon molecules that are converted to Acetyl, 2 carbon molecules (releasing 2 carbon as CO2).
Acetyl binds to CoA and enters the Krebs cycle and binds to Oxaloacetate (4) to form Citrate (6)
Through the Krebs cycle 2 CO2 are produced - returning to the base Oxaloacetate ready to accept another Acetyl.
So yes, through transition and the Krebs cycle, 6 carbons are released as CO2.
It is possible that the marked carbon is kept in the cycle and non-marked carbon is released - but I don't think that is how it works.