Fragile x or downs

[aspiringmd1015]

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which one is the mcc of inherited intellectual disability. sorry to make a thread just for this small question.

 

[ortnakas]

Most common cause = MCC?

Down's = #1, Fragile X = #2 according to DIT.

 

[aspiringmd1015]

UW says the oppoiste, my FA says what youre saying. UW usually trumps everyone.

 

[Postictal Raiden]

Down is not inherited, it's a chromosomal nondisjunction. On the other hand, Fragile X is x-linked inherited disease (CGG; anticipation; hypermethylation).

The way I see it, Down is the most common cause of intellectual disability, period. Fragile X is the most common inherited intellectual disability.

 

[ortnakas]

Down is not inherited, it's a chromosomal nondisjunction. On the other hand, Fragile X is x-linked inherited disease (CGG; anticipation; hypermethylation).

The way I see it, Down is the most common cause of intellectual disability, period. Fragile X is the most common inherited intellectual disability.

Just double-checked my notes and I agree with you. DIT actually says Down's and Fragile X are the #1 and #2 most common GENETIC causes, not #1 and #2 inherited.

 

[aspiringmd1015]

is downs more common than fetal alcohol syndrome?

 

[DrPicard]

As far as I'm aware, FAS is the no.1 cause of intellectual disability; Down is the no.1 genetic cause (less frequent than FAS), and fragile X the no.2 genetic cause. That would make fragile X the no.1 inherited cause, right?