Fructose

[beeitchness]

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How does fructose enter the cell?

Page 108 in FA 2012 under Essential fructosuria:

"A benign, asymptomatic condition, since fructose does not enter cells."

Does this mean that without fructokinase, fructose doesn't even bother going inside a cell? Or is it poorly worded and just implying that fructose gets in, doesn't become fructose 1 phosphate so it just builds up and spills out into the blood (which is what I had thought would happen)

 

[loveoforganic]

I assume the latter. Glut-5 works on fructose, not f6p, and fructokinase is a cytosolic enzyme anyway

 

[beeitchness]

Thanks.

Also, an irrelevant question about NADPH oxidase.
FA 2012 on page 107 says it's found in monocytes, but I recall in Pathoma, Dr. Sattar said macrophages do not have any oxygen dependent killing.
Does NADPH oxidase actually exist in macrophages, and if it does, do macrophages not use it for killing because they lack MPO or SOD?

I also realize monocytes are not the same as macrophages, perhaps they lose NADPH oxidase upon differentiation then?

 

[Dr McSexy]

I also realize monocytes are not the same as macrophages, perhaps they lose NADPH oxidase upon differentiation then?

I swear I remember reading something to this effect somewhere (maybe goljan).

 

[ctusfinest]

I swear I remember reading something to this effect somewhere (maybe goljan).

yea goljan audio says they lose it when they turn into macrophages

 

[MedFarmer]

also in UWorld...