furosemide effects on nephron concentration

[ktrn305]

I would appreciate clarification on this concept. Blocking the NaClK symporter of the TAL with furosemide should directly decrease urine dilution while directly increasing urine concentration in the nephron.... correct? You are are preventing solute reabsorption and leaving more in the nephron than normal. However, considering the single effect mechanism, blocking NaClK would still decrease urine dilution, but this also decreases the CP osmotic gradient of the interstitium, which would decrease urine concentration by causing less H2O reabsorption along the descending limb. So furosemide definitely decreases urine dilution, but increases and decreases urine concentration in different contexts?

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