G6PD deficiency

[Hokie06]

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On FA 2011 page 350, it has it under extravascular hemolysis and then on page 352, G6PD is listed as intravascular hemolysis.

Any thoughts? You see bite cells/heinz bodies with these so it makes sense it would be extravascular since it would be cleared by the reticuloendothelial system. but at the same time, can oxidation be so strong that you can also see intravascular hemolysis?

Thanks!

 

[Step1Hash]

On FA 2011 page 350, it has it under extravascular hemolysis and then on page 352, G6PD is listed as intravascular hemolysis.

Any thoughts? You see bite cells/heinz bodies with these so it makes sense it would be extravascular since it would be cleared by the reticuloendothelial system. but at the same time, can oxidation be so strong that you can also see intravascular hemolysis?

Thanks!

I think it's Intravascular. Since you see bite cells after the RES system took a piece out of it I would think that means they didn't get killed there. I have intravascular from my class notes as well but I could be wrong.

 

[jfgavina]

well, I think its both!

 

[dude1344]

The errata emphatically states it's both.