Step I Ganglion blockers

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watchmenaenae

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7+ Year Member
Hello, can anyone please explain to me how these agents work, Like hexamethonium . What exact receptors are these drugs blocking? how do they lower bp with tachycardia, are they competitive antagonists? Thanks in advance.


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just know that they block reflexes in ANS pharmacology experiments , and because they block ganglia you get the opposite of the dominant system (i.e. vasodilation and no sweating + SANS in everything else) , and the opposite happens if you stimulate the ganglia --> PANS in everything and vasoconstriction/sweating
 
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