GI Question

This forum made possible through the generous support of SDN members, donors, and sponsors. Thank you.

stookie

Slick Nasty
5+ Year Member
15+ Year Member
Joined
Oct 28, 2005
Messages
168
Reaction score
0
Say a 25 year old comes in with GERD and is being treated with an H2 blocker for 4 months and their symptoms persist, and has lost 5lbs, what would you do next? Change them to a PPI or perform an EGD?
My guess would be change them to a PPI given H2 blockers being less effacious than PPIs.
 
Say a 25 year old comes in with GERD and is being treated with an H2 blocker for 4 months and their symptoms persist, and has lost 5lbs, what would you do next? Change them to a PPI or perform an EGD?
My guess would be change them to a PPI given H2 blockers being less effacious than PPIs.

I would say EGD to r/o H. Pylori. If HP negative, than PPI.

I'll give my rationale behind it. 4 months worth of symptoms despite treatment are indications for EGD. I would say switching to PPI right away would not be appropriate without further investigation. Weight loss could be gastric ca, but since he is young, its probably more likely HP. Either way, you need EGD.

This is my best educated guess, if I'm wrong I'm welcome to a teaching lesson.
 
Last edited:
ppi, how do you know it's not just a g. ulcer, gotta try the 1st line tx.....
actually maybe u do scope, can you treat just based on th sx's?
 
Last edited:
ppi, how do you know it's not just a g. ulcer, gotta try the 1st line tx.....
actually maybe u do scope, can you treat just based on th sx's?

It could be gastric ulcer, but I don't think they would use weight loss as the primary symptom. People with HP have weight loss and persistant GERD symptoms. I also think that they are saying 4 months because they are trying to show that the symptoms are not responding to the H2 blocker.

In real life, they would scope at this point. If its H. Pylori, the PPI alone is not going to help. I wonder what the answer to the question is. OP, is this question out of the book or is it something you are asking based on a real patient?
 
Last edited:
It's a question that a friend of mine asked me. So scope huh?

If he is having symptoms that aren't any better after 4 months, than I would get scoped. Its better if he stops PPI 2 weeks before the EGD since it can cause a false negative for H. Pylori.
 
Oh sorry, maybe I should have explained. He's not having those symptoms, he's studying for step 2 and came across that question somewhere and can't seem to find an answer.
 
Oh sorry, maybe I should have explained. He's not having those symptoms, he's studying for step 2 and came across that question somewhere and can't seem to find an answer.

Thats OK, its easy to misinterpret things over the internet. This answer is my best guess, but of course I could be wrong. Please post here if you ever find the official answer and rationale.

If we take apart the question and see what info they are giving us, we can take our guesses as to what they are looking for.

25 years old
GERD symptoms persistant despite 4 months of treatment
Weight loss

I wouldn't say gastric CA would be the cause of weight loss. Not that its impossible, but I would think that is far fetched. Ulcers don't cause weight loss unless its due to anorexia secondary to pain. H. Pylori is transmitted by person to person contact. It's not uncommon for young adults to become infected.

They are telling you that the treatment is going on for 4 months because that is a long time for the treatment to be in place with no improvement. If they said 1 month, I would say that's borderline.

H. Pylori will cause persistant symptoms despite PPI or H2 given alone. This can be dx by EGD with biopsy, or by a blood and breath test. Since these are not options, EGD would be the choice.

persistant GERD + weight loss in a young person, I would conclude to be H. Pylori and would warrant an EGD rather than just starting PPI. They need a prevpac to treat this.
 
same exact question on uw but this guy had sx for 2 years.
they state:
it is a trial of ppi's for 8 weeks, if he fails therapy then scope him....
 
same exact question on uw but this guy had sx for 2 years.
they state:
it is a trial of ppi's for 8 weeks, if he fails therapy then scope him....

Well I guess that settles it then?? I can see reasoning behind both sides, wheter or not to scope or start the patient on a PPI.
 
Top