Gluconeogenesis location?

[yakuza]

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Ok so I know it occurs in primarily in the liver and kidney, within the cytosol. But wikipedia says that gluconeogenesis may begin in the mitochondria. Can someone explain this and the difference between beginning in the mitochondria vs the cytoplasm?

 

[hdu]

Some steps of gluconeogenesis occurs in mitochondria and others in cytosol.
metabolites of glycolysis, krebs cycle, amino acids, glycerol (P) can be used for the synthesis of glucose (gluconeogenesis). Depending of which of this compound the process begins, the gluconeogenesis can begin in mitochondria or in cytosol.

In fact, there are three important metabolic pathways that have reactions in mitochondria and in cytosol: Hem synthesis, Ureogenesis and Gluconeogenesis. A mnemonic to remember it is to recall that to give a HUG you need both arms

H em synthesis
U reogenesis
G luconeogenesis

(both arms: mitochondria and cytosol)

I hope it helps.

My blog: www.biochemistryquestions.wordpress.com

 

[yakuza]

Thanks man, it helps a lot.

I never heard of Ureogenesis though..but I'm about to look it up.

And also, the overall product is the same for both cytosol and mitochondria?

 

[hdu]

Answer to the first question:

Ureogenesis = Urea Cycle

Answer to the second question:

The final product of gluconeogenesis is glucose, it does not matter where it begins. Glucose is then exported to tissues that depends heavily on glucose for obtaining energy, like the brain, or Red Blood cells.

Gluconeogenesis is important in intermeal periods, and of course, during starvation.

 

[klutzy1987]

I assume that ureogenesis is the opposite of the corey cycle. Or is it another name for the corey cycle ??

 

[atlanta213]

hem synthesis? hemoglobin?

 

[hdu]

Sorry. I do not want to confuse you giving more information that you need (I do not really know how much you need).

Ureogenesis is Urea cycle = synthesis of Urea. It occurs in the liver.

Hem synthesis = process of synthesis of the Hem group. The Hem group appears not only in Hemoglobin, but also in myoglobin and in cytochromes and other enzymes.

If you do not need to know it, then focus in what you need to know and disregard this comment.

 

[hdu]

Answer to the first question:

Ureogenesis = Urea Cycle

Answer to the second question:

The final product of gluconeogenesis is glucose, it does not matter where it begins. Glucose is then exported to tissues that depends heavily on glucose for obtaining energy, like the brain, or Red Blood cells.

Gluconeogenesis is important in intermeal periods, and of course, during starvation.

OK, I had to edit it becaause it was not clear that I was ansering to the two different questions.

Your other question:

Cory cycle is a physiological cycle, more than a biochemical cycle:

Corey cycle:

Muscle during contraction use glucose. lactate is produced (anaerobic glycolysis)
Lactate diffuses from muscle to blood and then to liver
Liver uses lactate to form glucose (gluconeogenesis)
the glucose that is formed in the liver is send again to the muscle

And the cycle begins again...

(Muscular pains after intense exercise are a consequence of the accumulation of lactate that irritates the nervous endings in muscle)

 

[klutzy1987]

OK, I had to edit it becaause it was not clear that I was ansering to the two different questions.

Your other question:

Cory cycle is a physiological cycle, more than a biochemical cycle:

Corey cycle:

Muscle during contraction use glucose. lactate is produced (anaerobic glycolysis)
Lactate diffuses from muscle to blood and then to liver
Liver uses lactate to form glucose (gluconeogenesis)
the glucose that is formed in the liver is send again to the muscle

And the cycle begins again...

(Muscular pains after intense exercise are a consequence of the accumulation of lactate that irritates the nervous endings in muscle)

Im sorry i didnt mean corey cycle i meant the ornithine cycle. That is ureogenesis or is that the opposite?

 

[Mstoothlady2012]

OK, I had to edit it becaause it was not clear that I was ansering to the two different questions.

Your other question:

Cory cycle is a physiological cycle, more than a biochemical cycle:

Corey cycle:

Muscle during contraction use glucose. lactate is produced (anaerobic glycolysis)
Lactate diffuses from muscle to blood and then to liver
Liver uses lactate to form glucose (gluconeogenesis)
the glucose that is formed in the liver is send again to the muscle

And the cycle begins again...

(Muscular pains after intense exercise are a consequence of the accumulation of lactate that irritates the nervous endings in muscle)

I thought this was called Cori cycle. Is that another name for it? All these similar names drive me crazzzzyyy🙄

 

[hdu]

you are right. Cori cycle is the name. My fault