gluconeogenesis question

[theonlytycrane]

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To clarify, the net deltaG < 0 for gluconeogenesis only when considering the ATP hydrolysis involved, correct?

PS I hate the new KA layout. /end rant

 

[aldol16]

To clarify, the net deltaG < 0 for gluconeogenesis only when considering the ATP hydrolysis involved, correct?

Yeah - it's the net reaction, which involves loss of ATP.

 

[Lawpy]

To clarify, the net deltaG < 0 for gluconeogenesis only when considering the ATP hydrolysis involved, correct?

Yeah - it's the net reaction, which involves loss of ATP.

I agree but it's a rather bad question. Why? Because every metabolic reaction must be spontaneous in order for the cellular needs to be carried out, so deltaG will always be negative. This means that reactions that don't seem to be spontaneous (like in anabolism/biosynthesis) would require ATP consumption for them to run.