Dismiss Notice
Hey Texans—join us for a DFW meetup! Click here to learn more.

GM-CSF versus G-CSF

Discussion in 'Step I' started by DwyaneWade, May 12, 2008.

  1. DwyaneWade

    DwyaneWade Reiging *** Cynic
    10+ Year Member

    Joined:
    May 7, 2006
    Messages:
    669
    Likes Received:
    0
    Status:
    Resident [Any Field]
    Could anyone please help me understand the basic difference between these two? None of my resources really seem to address this, and websearching just yielded a bunch of papers comparing efficacy. What are the major distinguishing factors in term of side effects and indications?
     
  2. Note: SDN Members do not see this ad.

  3. myry

    myry countdown
    7+ Year Member

    Joined:
    Jul 18, 2003
    Messages:
    57
    Likes Received:
    2
    GM-CSF and G-CSF stimulate hematopoietic cells.

    GM-CSF (granulocyte-macrophage colony-stimulating factor):
    - stimulates production of granulocytes (mostly neutrophils) and monocytes/macrophages
    - used clinically to improve regeneration of these cells after bone marrow transplant

    G-CSF (granulocyte colony-stimulating factor):
    - stimulates production of granulocytes (mostly neutrophils)
    - used clinically to prevent infections in pts who have received chemo

    Hope that helps...
     
  4. myry

    myry countdown
    7+ Year Member

    Joined:
    Jul 18, 2003
    Messages:
    57
    Likes Received:
    2
    Filgrastin and Sargramostim are almost identical to G-CSF annd GM-CSF, respectively. The main side effect of G-CSF if bone pain, which resolves after discontinuing drug. GM-CSF is associated with fever, arthralgia, edema, and pleural and pericardial effusion.
     
  5. DwyaneWade

    DwyaneWade Reiging *** Cynic
    10+ Year Member

    Joined:
    May 7, 2006
    Messages:
    669
    Likes Received:
    0
    Status:
    Resident [Any Field]
    Thanks!
     

Share This Page