GM-CSF versus G-CSF

[DwyaneWade]

Could anyone please help me understand the basic difference between these two? None of my resources really seem to address this, and websearching just yielded a bunch of papers comparing efficacy. What are the major distinguishing factors in term of side effects and indications?

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[myry]

GM-CSF and G-CSF stimulate hematopoietic cells.

GM-CSF (granulocyte-macrophage colony-stimulating factor):
- stimulates production of granulocytes (mostly neutrophils) and monocytes/macrophages
- used clinically to improve regeneration of these cells after bone marrow transplant

G-CSF (granulocyte colony-stimulating factor):
- stimulates production of granulocytes (mostly neutrophils)
- used clinically to prevent infections in pts who have received chemo

Hope that helps...

 

[myry]

Filgrastin and Sargramostim are almost identical to G-CSF annd GM-CSF, respectively. The main side effect of G-CSF if bone pain, which resolves after discontinuing drug. GM-CSF is associated with fever, arthralgia, edema, and pleural and pericardial effusion.

 

[DwyaneWade]

Filgrastin and Sargramostim are almost identical to G-CSF annd GM-CSF, respectively. The main side effect of G-CSF if bone pain, which resolves after discontinuing drug. GM-CSF is associated with fever, arthralgia, edema, and pleural and pericardial effusion.

Thanks!