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GM-CSF versus G-CSF

Discussion in 'Step I' started by DwyaneWade, May 12, 2008.

  1. DwyaneWade

    DwyaneWade Reiging *** Cynic
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    Could anyone please help me understand the basic difference between these two? None of my resources really seem to address this, and websearching just yielded a bunch of papers comparing efficacy. What are the major distinguishing factors in term of side effects and indications?
     
  2. myry

    myry countdown
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    GM-CSF and G-CSF stimulate hematopoietic cells.

    GM-CSF (granulocyte-macrophage colony-stimulating factor):
    - stimulates production of granulocytes (mostly neutrophils) and monocytes/macrophages
    - used clinically to improve regeneration of these cells after bone marrow transplant

    G-CSF (granulocyte colony-stimulating factor):
    - stimulates production of granulocytes (mostly neutrophils)
    - used clinically to prevent infections in pts who have received chemo

    Hope that helps...
     
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  3. myry

    myry countdown
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    Filgrastin and Sargramostim are almost identical to G-CSF annd GM-CSF, respectively. The main side effect of G-CSF if bone pain, which resolves after discontinuing drug. GM-CSF is associated with fever, arthralgia, edema, and pleural and pericardial effusion.
     
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  4. OP
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    DwyaneWade

    DwyaneWade Reiging *** Cynic
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    Thanks!
     

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