Good Kinetics Textbook/Guide

[Sparda29]

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Anybody know a textbook or guide that explains Pharmacokinetics well?

The question I was given was: 325 mg of a drug is administered as a single IV bolus to a 40 year old male. And then they give me the plasma concentration over a 24 hour period. From the data, I'm able to plot out a graph.

Now, here is where I am totally stumped as I cannot find any of the equations for these parameters in my textbook.

The parameters are:

A, Alpha, B, Beta, k10, k12, k21, V1, V(area)/V(ex), V(beta), V(ss), CL, AUC.

From what I know, I've figured out that AUC stands for area under the curve, which I can figure out from the trapezoidal rule. CL is clearance, V has to be volume, I guess k means the rate constant, but I don't know what the numbers next to it mean, I'm guessing the numbers are probably the hour (probably means this drug doesn't have a constant rate)

A, Alpha, B, and Beta, I have no idea at all what these parameters represent.

Any good guides out there for this stuff? I have the textbook called, Applied Clinical Pharmacokinetics by Larry A. Bauer but I don't see an equation list.

 

[crazybob]

i haven't had pharmacokinetics yet, but i think i've found something that might be able to help you.

http://www.digitalcalculus.com/example/pharmacokinetics.html

http://www.scribd.com/doc/503851/BASIC-PHARMACOKINETICS-CHAPTER-11-Multicompartment-model

http://books.google.com/books?id=_F...esult&ct=result&resnum=1#v=onepage&q=&f=false

 

[sherlockRX]

Looks like this is a typical problem of two-compartment model where you have the distribution phase (alpha) and elimination phase (beta).

[Comp 1 (central) - blood and well perfused organs, e.g. liver, kidney, etc.; "plasma" . Comp 2 (peripheral) - poorly perfused tissues, e.g. muscle, lean tissue, fat; "tissue"


k12 or k21 is designated for the direction you go from either compartment to the other one.


An equation with only one exponential term cannot describe this curve. Two are required.

Your book should have the section for this. Any pharmacokinetic book should have...

 

[npage148]

gibaldi and perrier

get it, learn it, love it.


but yeah, those parameters are for a 2CM model. I could tell you what A and B are in terms of k10, k12, k21 but I don't feel like looking it up or deriving it.

 

[p-rog]

Looks like this is a typical problem of two-compartment model where you have the distribution phase (alpha) and elimination phase (beta).

[Comp 1 (central) - blood and well perfused organs, e.g. liver, kidney, etc.; "plasma" . Comp 2 (peripheral) - poorly perfused tissues, e.g. muscle, lean tissue, fat; "tissue"


k12 or k21 is designated for the direction you go from either compartment to the other one.


An equation with only one exponential term cannot describe this curve. Two are required.

Your book should have the section for this. Any pharmacokinetic book should have...

Exactly. It's strange that it seems you were assigned a problem like this without ever having been taught it. Anyways, just google "two compartmental model kinetics" and you should be able to find plenty of sites that break it all down for you.

 

[Praziquantel86]

gibaldi and perrier

get it, learn it, love it.

Spoken like a Buffalo grad...

I don't know why they switched us to that Roland and Tozer garbage.

 

[Sparda29]

Exactly. It's strange that it seems you were assigned a problem like this without ever having been taught it. Anyways, just google "two compartmental model kinetics" and you should be able to find plenty of sites that break it all down for you.

I'm pretty sure it was taught, but I think I was probably concentrating more on Therapeutics at the time it was taught. It doesn't help that our kinetics professor has a heavy Russian accent.

 

[p-rog]

In Soviet Russia, drug takes your peak and trough levels!

 

[Quiksilver]

Looks like this is a typical problem of two-compartment model where you have the distribution phase (alpha) and elimination phase (beta).

[Comp 1 (central) - blood and well perfused organs, e.g. liver, kidney, etc.; "plasma" . Comp 2 (peripheral) - poorly perfused tissues, e.g. muscle, lean tissue, fat; "tissue"


k12 or k21 is designated for the direction you go from either compartment to the other one.


An equation with only one exponential term cannot describe this curve. Two are required.

Your book should have the section for this. Any pharmacokinetic book should have...

This is as good of a post you are going to get for an explanation. I would get into it but its too time consuming and as others have said it is easily found in any kinetics books. Consult your notes because I find it hard to believe that there was not an example that was given to you.

so gibaldi has a good kinetics book?