Goosecoid question

[psipsina]

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Hi y'all. As HPD is my current archnemesis, and I haven't been able to find the answer to this in my various texts I put it to the brilliant minds of SDN:

My proff talked about the TF goosecoid and its role in dorsalization of the mesoderm, but he never said where on earth the goosecoid was coming from? Does anyone know. It seems like its an important piece of this maddening puzzle. Thanks!

 

[Docster]

GOOSECOID is expressed by the primitive node

 

[psipsina]

GOOSECOID is expressed by the primitive node

Thanks so much, now all makes sense 😀

 

[Dunce]

It seems like its an important piece of this maddening puzzle

That other persons answer can help you on the test.

However, let me reassure all the other people who read your post and thought, "Goosecoid? What the heck is goosecoid? 😱 " Trust me. It is not important. File it under M for minutiae. 😉

 

[psipsina]

That other persons answer can help you on the test.

However, let me reassure all the other people who read your post and thought, "Goosecoid? What the heck is goosecoid? 😱 " Trust me. It is not important. File it under M for minutiae. 😉

Yah, I just couldn't grasp the larger concept of dorsalization without understanding where the TF was coming from.

 

[THP]

I made it through the first 2 years of medical school in the top 20% of my class and I have never heard of goosecoid, TF, the primitive node or dorsalization. However, I have heard of mesoderm.

 

[jennben4]

I made it through the first 2 years of medical school in the top 20% of my class and I have never heard of goosecoid, TF, the primitive node or dorsalization. However, I have heard of mesoderm.

Thank you! Mesoderm, check. Primitive node, check. Dorsalization, maybe. The rest = Greek.

 

[psipsina]

I think its odd that y'all are reacting to my question this way. I was just trying to visualize a concept and had a missing piece that my brain needed to wrap itself around it. Its awesome that you guys did so well without having to know this stuff but sometimes minutae really helps me get the bigger picture, its just how I learn. Whatever works right?
Oh and just FYI, 50% of my embryo test will be on genetics, so maybe my school just has a different emphaisis than yours.

 

[Docster]

hmm it's funny b/c i'm taking embryology/histo/anatomy right now and had just gone over gastrulation during week 3 when i saw ur post....

i'm sure goosecoid being an antagonist of BMP-4 isn't important in the broader scheme of clinical medicine (although its over- or under-expression causes head malformations like duplication!), but for those taking embryology, names of signalling factors & their temporal/spatial relationships appear on exams

 

[Dunce]

I think its odd that y'all are reacting to my question this way. I was just trying to visualize a concept and had a missing piece that my brain needed to wrap itself around it. Its awesome that you guys did so well without having to know this stuff but sometimes minutae really helps me get the bigger picture, its just how I learn. Whatever works right?
Oh and just FYI, 50% of my embryo test will be on genetics, so maybe my school just has a different emphaisis than yours.

..wasn't meaning to be rude or anything but I see how it might have been interpreted that way. Keep asking questions in the future. Nobody can ever knock you for trying to learn or better understand a concept.
This was just a reminder of how we all spend so much time learning these crazy off-the-wall facts and somehow end up putting it all together and making sense of things in the end.

p.s. -- it took me a good thirty seconds to decipher what I was staring at when trying to read the word "goosecoid"