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This has probably been asked many times before, but what does everyone think about USMLE scores vs. pre-clinical grades? There is obviously no clear-cut answer, but I am wondering what people think. As far as I know, third year grades and board scores are most important, first and second year grades much less so. Of course, there is the argument that people who do very well the first two years will do very well on the USMLE and during the clinical years, but several people have told me this is not necessarily the case, especially when a school's curriculum is not geared towards the boards. Ideally, one would do exceptionally well in classes and on the boards. Would it therefore be a horrible idea to sacrifice one's grades to some extent (i.e., be average at top 10 school) to start preparing for the USMLE during the first year (i.e., spending lots of time studying for classes and a fair amount of time studying for the USMLE instead of spending all of the time studying for classes)? It would seem so, considering that many, many programs have USMLE cut-offs, but very few--at least as far as I know--have pre-clinical grade cut-offs. (The caveat here is that pre-clinical grades are part of one's overall academic performance, which is judged to be very important.) Furthermore, considering that many residency programs use 'school reputation' as a modifier in evaluating academic performance, it would seem that doing well on the USMLE is paramount, since it is the one common yardstick in the process. I am interested in peoples' thoughts regarding this difficult and contentious topic.