Growth Hormone Confusion! Please Help!

[masterofnone101]

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So I understand that growth hormone is inhibited by glucose according to FA. And that GH causes insulin resistance.

Inorder to put the big picture together - so does GH cause insulin resistance in obesity which results in hyperglycemia leading to fat gain in obesity? And then does the high glucose inhibit GH release in obesity?

Also I understand that GH also releases IGF-1..whats the signifance of IGF-1? Does it work like insulin? Does it promote the actual linear growth?

 

[worldbeater]

so does GH cause insulin resistance in obesity which results in hyperglycemia leading to fat gain in obesity? And then does the high glucose inhibit GH release in obesity?

I am not sure about growth hormone, but it is a downward spiral in terms obesity causes insulin resistance and then more obesity causes more insulin resistance, etc.

whats the signifance of IGF-1

Growth hormone stimulates IGF-1 from the liver, which goes to the growth plates to cause growth of bones, tendons, muscles, etc.

Additional points:
-Only comes out during the first REM cycle, so children only grow while asleep

 

[stop2stop]

So I understand that growth hormone is inhibited by glucose according to FA. And that GH causes insulin resistance.

Inorder to put the big picture together - so does GH cause insulin resistance in obesity which results in hyperglycemia leading to fat gain in obesity? And then does the high glucose inhibit GH release in obesity?

Also I understand that GH also releases IGF-1..whats the signifance of IGF-1? Does it work like insulin? Does it promote the actual linear growth?

I'm not sure I would bring the GH obesity association together like that unless you're talking about specific circumstances like Acromegaly (And again not sure obesity totally applies here though).

Sounds like you need to go back and read on this a bit more, but essentially GH leads to insulin resistance (So we're going to be breaking down fat), protein synthesis, and stimulates IGF-1 from the liver. The production of IGF-1 from the liver is really the workhorse here, which goes on to stimulate growth. To your point about it being inhibited by glucose, that makes a ton of sense. Endocrinology is all about feedback mechanisms, almost universally across the subject. So when glucose goes up (Which remember GH is directly causing via insulin resistance) then that same glucose is going to feedback and say "Enough, we're good, stop making GH," which is negative feedback.

As worldbeater mentioned, there are a ton of additional points worth knowing with these mechanisms, their receptors, etc. but I would try to get down the basic there first before moving on.

 

[Phloston]

Growth hormone isn't just for growth. It also promotes maintaining blood glucose levels through insulin resistance modulation. Igf-1 is released by the liver in response to GH and is the predominant mediator.