Step I GT: warfarin

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trgf

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Gunnertraining: Warfarin
paradoxical thrombosis can be treated via fresh frozen plasma because it contains coagulation factors and vitamin k. shouldn't it be because plasma contains protein C and S, which have short half-lives? also, heparin and enoxoparins could be used as well, correct? Thanks so much in advance!
 
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trgf said:
Gunnertraining: Warfarin
paradoxical thrombosis can be treated via fresh frozen plasma because it contains coagulation factors and vitamin k. shouldn't it be because plasma contains protein C and S, which have short half-lives? also, heparin and enoxoparins could be used as well, correct? Thanks so much in advance!
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You're right. Treatment of thrombosis in these patients is not related with coagulation factors. FFP is used because it contains proteins C and S. Heparin, LMWH, vitamin K and activated protein C (Xigris - also used in sepsis) can also be used to treat it.
 
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