Gynecomastia in Choricarcinoma

[cue68]

---

Members do not see this ad.

Can anyone explain me the pathophysiology of gynecomastia in Choriocarcinoma?
B-hCG (LH Analogue) -> ? ? ?

 

[Phloston]

Abstract from

Am J Med. 1986 Nov;81(5):917-20.
Endocrine studies in a male patient with choriocarcinoma and gynecomastia.
Whitcomb RW, Schimke RN, Kyner JL, Lukert BP, Johnson DC.

"Sex hormone profiles were studied in serum and tumor extracts of a man with pulmonary choriocarcinoma and gynecomastia. Although levels of serum estrogens were elevated as expected, serum androgen levels were uncharacteristically quite high. Tumor extract contained increased quantities of both androgens and estrogens when compared with surrounding normal lung tissue, but lacked the enzymes necessary for androgen biosynthesis while retaining aromatase activity. It is concluded that unlike the usual male patient with choriocarcinoma, the tumor-derived beta-human chorionic gonadotropin stimulated testicular androgen production. These androgens were in turn concentrated by the tumor and converted in part to estrogens. Furthermore, gynecomastia can occur even in the face of high serum androgen concentrations provided total estrogen levels are also disproportionately elevated."

 

[HSE21]

Abstract from

Am J Med. 1986 Nov;81(5):917-20.
Endocrine studies in a male patient with choriocarcinoma and gynecomastia.
Whitcomb RW, Schimke RN, Kyner JL, Lukert BP, Johnson DC.

"Sex hormone profiles were studied in serum and tumor extracts of a man with pulmonary choriocarcinoma and gynecomastia. Although levels of serum estrogens were elevated as expected, serum androgen levels were uncharacteristically quite high. Tumor extract contained increased quantities of both androgens and estrogens when compared with surrounding normal lung tissue, but lacked the enzymes necessary for androgen biosynthesis while retaining aromatase activity. It is concluded that unlike the usual male patient with choriocarcinoma, the tumor-derived beta-human chorionic gonadotropin stimulated testicular androgen production. These androgens were in turn concentrated by the tumor and converted in part to estrogens. Furthermore, gynecomastia can occur even in the face of high serum androgen concentrations provided total estrogen levels are also disproportionately elevated."

Pholston........... you're a good man.
"nothing to contribute"

 

[ZGX]

Can anyone explain me the pathophysiology of gynecomastia in Choriocarcinoma?
B-hCG (LH Analogue) -> ? ? ?

Hello cue68,

Choriocarcinoma secretes Beta-HCG.
Beta-HCG has an alpha subunit that is very similar to FSH, LH, TSH, hence the Gynocomastia, hyperythyroidism.
Because Choriocarcinoma is a malignant tumor of synctiotrophoblasts & cytotrophoblasts, they have a tendency to spread via blood.

 

[HSE21]

Hello cue68,

Choriocarcinoma secretes Beta-HCG.
Beta-HCG has an alpha subunit that is very similar to FSH, LH, TSH, hence the Gynocomastia, hyperythyroidism.
Because Choriocarcinoma is a malignant tumor of synctiotrophoblasts & cytotrophoblasts, they have a tendency to spread via blood.

I think hCG have an alpha and a beta submit. and the beta-hCG is the one that is secreted in the tumour.

 

[cue68]

Abstract from

Am J Med. 1986 Nov;81(5):917-20.
Endocrine studies in a male patient with choriocarcinoma and gynecomastia.
Whitcomb RW, Schimke RN, Kyner JL, Lukert BP, Johnson DC.

"Sex hormone profiles were studied in serum and tumor extracts of a man with pulmonary choriocarcinoma and gynecomastia. Although levels of serum estrogens were elevated as expected, serum androgen levels were uncharacteristically quite high. Tumor extract contained increased quantities of both androgens and estrogens when compared with surrounding normal lung tissue, but lacked the enzymes necessary for androgen biosynthesis while retaining aromatase activity. It is concluded that unlike the usual male patient with choriocarcinoma, the tumor-derived beta-human chorionic gonadotropin stimulated testicular androgen production. These androgens were in turn concentrated by the tumor and converted in part to estrogens. Furthermore, gynecomastia can occur even in the face of high serum androgen concentrations provided total estrogen levels are also disproportionately elevated."

Good Man Indeed! Thanks. The entire time it was driving me nuts as to why increased Testostrone would lead to gyneo.