Hey
I have a case of sudden death, someone in their later 70s. The micro work showed - Congo Red staining deposits both in the blood vessels as well focally in some parts of the myocardium and just blood vessels in colon and lungs. The patient had a history of IBD from previous biopsies and clinical data. In the kidneys, there are some eosinophilic deopsits that do not stain with Congo Red.
The thing is that immunohisto with for Amyloid AA showed positive results in the heart and the colon and partially positive for the lungs. Here is the thing, none of the slides in these tissues show birefringence.!!
So far the causes of death I think is cardiomyopathy. Am wondering if it is amyloidosis and if so, is it primary or secondary!
(No previous clinical data suggested amyloidosis, the vessels with deposits have narrowed lumens.)
Any thoughts?? Thanks in advance.
I have a case of sudden death, someone in their later 70s. The micro work showed - Congo Red staining deposits both in the blood vessels as well focally in some parts of the myocardium and just blood vessels in colon and lungs. The patient had a history of IBD from previous biopsies and clinical data. In the kidneys, there are some eosinophilic deopsits that do not stain with Congo Red.
The thing is that immunohisto with for Amyloid AA showed positive results in the heart and the colon and partially positive for the lungs. Here is the thing, none of the slides in these tissues show birefringence.!!
So far the causes of death I think is cardiomyopathy. Am wondering if it is amyloidosis and if so, is it primary or secondary!
(No previous clinical data suggested amyloidosis, the vessels with deposits have narrowed lumens.)
Any thoughts?? Thanks in advance.
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