Hereditary Hemochromatosis & CPPD

[futuredoctor10]

I know that hereditary hemochromatosis is one of the causes of calcium pyrophosphate crystal deposition disease (pseudogout). Why does this happen?

I remember learning that calcium interferes with iron absorption, but not the other way around (so I am unclear why increased iron absorption would affect/increase calcium levels).

Probably don't have to know why/how this works for Step 2, but was just curious. In my brief search online I could not find how. I am guessing somehow the increased iron deposition in the joints causes increased calcifications and can lead to pseudogout.

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[StrangerX]

I believe the reason is that hemochromatosis probably results in joint damage. Any time you get joint damage you are prone to getting CPDD in that joint.

 

[Bob Rogers]

I am very pleased to see medical students discussing the conditions and diseases caused by hereditary hemochromatosis. CPPD in this case is the direct result of too much iron being deposited in joint tissues and inflammation. The build up of calcium pyrophosphate crystals and fluid occurs. Treatment for CPPD is to aspirate the fluid from the affected area.

The build up of this fluid on the second and third knuckles of the hand is a classic symptom of hereditary hemochromatosis.

Bob Rogers
Executive Director
Canadian Hemochromatosis Society
www.toomuchiron.ca

 

[futuredoctor10]

I am very pleased to see medical students discussing the conditions and diseases caused by hereditary hemochromatosis. CPPD in this case is the direct result of too much iron being deposited in joint tissues and inflammation. The build up of calcium pyrophosphate crystals and fluid occurs. Treatment for CPPD is to aspirate the fluid from the affected area.

The build up of this fluid on the second and third knuckles of the hand is a classic symptom of hereditary hemochromatosis.

Bob Rogers
Executive Director
Canadian Hemochromatosis Society
www.toomuchiron.ca

Thank you for your comments/response! I did not know that fluid buildup on the 2nd and 3rd knuckles is a classic symptom. Good to know.