• A new admissions hurdle is becoming more common: the CASPer test. Learn more about it at a free webinar hosted by SDN and PrepMatch on May 6th. Register now!

Gilakend

7+ Year Member
Aug 24, 2012
1,675
3,248
Status (Visible)
  1. Medical Student
On AAMC FL 1 B/B #55 it states that the brain uses insulin-independent methods of glucose uptake which is why diabetic brains receive adequate nourishment. I was wondering if anyone knew why pts with high blood sugar then had altered mental status and can often appear "drunk"? Is it because of the high concentration? I tried to google it but couldn't figure out how to word it.

Thanks!
 

Nugester

2+ Year Member
Jul 4, 2017
791
782
Status (Visible)
  1. Medical Student
Patients with diabetes have high blood sugar. They take insulin to control the amount of blood sugar. If they take a shot of insulin and forget to eat or eat too little, they suffer from insulin shock or hypoglycemia, which results in the drunk appearance you speak of.
 
  • Like
Reactions: 1 user

Lawpy

28 boxes
5+ Year Member
SDN Ambassador
Jun 17, 2014
54,200
143,660
Replacement Chat
forums.studentdoctor.net
On AAMC FL 1 B/B #55 it states that the brain uses insulin-independent methods of glucose uptake which is why diabetic brains receive adequate nourishment. I was wondering if anyone knew why pts with high blood sugar then had altered mental status and can often appear "drunk"? Is it because of the high concentration? I tried to google it but couldn't figure out how to word it.

Thanks!

The brain, like any organ, works best under normal, physiological conditions. When there are imbalances, homeostatic mechanisms kick in to restore to normal levels. But sometimes, feedback mechanisms don't work and can actually worsen the problem, leading to abnormal signs and symptoms.

Altered mental status is one medical symptom and indicates that something is going wrong. In cases of high blood sugar levels, the brain uses glucose transporters to take in as much glucose as possible. But glucose transport occurs via facilitated diffusion because glucose is a polar molecule. Transporters have a limit on how much glucose they can transport, and once that limit is exceeded, there will still be excess glucose in the blood. That's why insulin is helpful for stimulating glucose uptake but even that can fail in cases of uncorrected hyperglycemia. More glucose in the blood means increased plasma osmolarity. This leads to a medical complication called hyperosmolar hyperglycemic state which can be fatal if not immediately treated. Hyperosmolar Hyperglycemic State: Background, Pathophysiology, Etiology
 
  • Like
Reactions: 1 user
About the Ads
This thread is more than 3 years old.

Your message may be considered spam for the following reasons:

  1. Your new thread title is very short, and likely is unhelpful.
  2. Your reply is very short and likely does not add anything to the thread.
  3. Your reply is very long and likely does not add anything to the thread.
  4. It is very likely that it does not need any further discussion and thus bumping it serves no purpose.
  5. Your message is mostly quotes or spoilers.
  6. Your reply has occurred very quickly after a previous reply and likely does not add anything to the thread.
  7. This thread is locked.