I don't think it matters a great deal. I'm in the semi-Honors program for biology majors and all I've done was take one 4-credit honors Biology course, and 2-3 credits of Biology honors seminar. The 4-credit honors course was different from the regular course in that it had no curve, had a couple article summaries, and a poster presentation. The 2-3 credits of honors seminar was just a discussion based course on evolution books. Is it all worth it? Probably not but I only signed up for the honors program because my undergraduate isn't top-tier (it's ranked ~140 on U.S. News. My decision was more ego based than anything else.