Hormones that act via a secondary messenger system

[bestinthewest]

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The 3 particular hormones that I have down that act via a SMS are ACTH, TSH, and glucagon. I'd be remiss to think that these are the only 3. Are there any other noteworthy hormones that should be classified as such? Thanks

 

[ELTURC0]

As far as I know all the peptide hormones act via a SMS since they can't pass through the bilayer membrane. These hormones need to bind to a membrane bound protein receptor and thus exert their effects through a SMS in the cell. All the steroid hormones and tyrosine derivatives have their receptors in the cytosol/nucleus and don't necessarily need a SMS. Hope this helps.

 

[azor ahai]

steroid hormones/thyroid hormones can bypass the lipid bilayer and nuclear membrane allowing them to affect gene transcription.

peptide hormones/catecholamines cannot do that because they're hydrophilic, so they must act via second messenger which results in amplification

 

[erythrocyte666]

yeah all peptide and most small molecule hormones induce second messenger system; notable exception to small molecule hormones is thyroid hormone which, despite an amino acid derivative, binds to nuclear receptors