- Joined
- Nov 5, 2014
- Messages
- 1,301
- Reaction score
- 1,474
I'm an M1. There's been so much info thrown at me in the past 3-4 weeks that everything just seems so fuzzy in my head.
If you asked me about purine synthesis, I would be able to tell you that the committed step where an amino group is added to PRPP is inhibited by 6-mercaptopurine and that methotrexate inhibits IMP synthesis through stopping reduction of folic acid. But if you ask me for enzymes I MIGHT be able to recognize a few if presented in a multiple choice format. If you ask me for structures I'll probably not be able to identify many. I know Lesch Nyhan is a deficiency in HPGRT (whatever that stands for) which results in more PRPP and decreased IMP and GMP production but that's it. I really don't know anything else about salvage pathways. I only know purine degradation as it relates to gout.
This level of understanding is pretty true across the board for me. I could remember all of the steps and enzymes and disease pathologies if I were given enough time, but there's too much info to remember. Everything in my head is just in a hazy state of halfway knowing. Is this normal? I feel like the info is crystal clear for some of my classmates. I just do ok enough on tests to pass by a moderate margin.
If you asked me about purine synthesis, I would be able to tell you that the committed step where an amino group is added to PRPP is inhibited by 6-mercaptopurine and that methotrexate inhibits IMP synthesis through stopping reduction of folic acid. But if you ask me for enzymes I MIGHT be able to recognize a few if presented in a multiple choice format. If you ask me for structures I'll probably not be able to identify many. I know Lesch Nyhan is a deficiency in HPGRT (whatever that stands for) which results in more PRPP and decreased IMP and GMP production but that's it. I really don't know anything else about salvage pathways. I only know purine degradation as it relates to gout.
This level of understanding is pretty true across the board for me. I could remember all of the steps and enzymes and disease pathologies if I were given enough time, but there's too much info to remember. Everything in my head is just in a hazy state of halfway knowing. Is this normal? I feel like the info is crystal clear for some of my classmates. I just do ok enough on tests to pass by a moderate margin.