How do loops decrease RBF??

[skyblue2000]

---

Members don't see this ad.

According to UW, loops cause increase creatinine levels by decreases RBF..

Can someone please explain this to be.. since I figure because loops increase prostaglandins, they would INCREASE RBF.

 

[ChessMaster3000]

Loops have nothing to do with increasing prostaglandins.

 

[skyblue2000]

Not according to FA and UW..

and http://www.ncbi.nlm.nih.gov/pubmed/2600809

 

[ChessMaster3000]

Damn I guess I was wrong. However, I think the overriding factor would still be decreased RBF from a natriuresis, which is the main mechanism of loops. Whatever prostaglandin effect it does have, wold be well compensated for by its primary MOA