How does Rhogam not induce hemolysis in the fetus?

[Blesbok]

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If it is given at 28 weeks and IgG crosses the placenta, shouldn't it induce hemolysis in the infant?

 

[Occams Razor]

I dont think Rhogam crosses the placenta.

Check this out for more information.

http://forums.studentdoctor.net/showthread.php?t=413127

 

[Blesbok]

I dont think Rhogam crosses the placenta.

Check this out for more information.

http://forums.studentdoctor.net/showthread.php?t=413127

Thanks. Funny that someone asked the same thing.

Here is an excerpt for anyone reading this thread

Before administration, fetal RBCs are quantitated in order to determine the proper dose of RhIG.

RhIG is IgG antibody. It will cross the placenta and can cause a weakly positive DAT in the fetus/infant. However, the titer of anti-D is too weak to cause any clinically significant RBC destruction.

 

[bbpiano1]

Why not just use IgM (more phagocytic and won't cross placenta)? Any immunologists out there?

 

[Blesbok]

Why not just use IgM (more phagocytic and won't cross placenta)? Any immunologists out there?

IgG is more phagocytic. At least in a direct sense.