As it is right now, I have only one shot. Given the opportunity I would apply a second time, if I had learned where I needed room to improve (eg more time to get experience, shadowing, additional non-required yet helpful coursework).
I'm a 40 yr old mom with 4 kids and an active duty military husband. We move a lot; we cannot afford to run two households and I need him, when he is around, to help with the kids if I am in Pharmacy school.
If I don't get in this time, I will likely go for my backup plan. If I decide I really want to give it a second shot, I may reapply to the same school and perhaps Creighton for the following cycle. (though I have no idea how I would do the on-campus requirements for Creighton anyway, but I don't have the luxury of applying wherever).