None. Zero. Zippo.
I submitted 28 applications for General surgery, got 18 interview offers and went to 14 interviews. Never once was my undergrad GPA of any issue at all.
This is truly a blessing if you are like me...less than stellar start to undergrad, shaped up later in the undergrad career. For me, the bad start was about 20 years prior to my med school applciation, and caused me some trouble with the admissions process (I had to apply twice and take addtional undergrad classes to prove myself). Now, for the first time, the stuff from 20 years ago was completely irrelevant (as it should be). I found I had to explain that my undergrad start wasn't great to partially answer the question why I waited so long for med school
Now, one place I applied sent me a secondary application. It asked for, of all things my high school SAT scores!!!. I didn't fill it out, I decided that any place that cared what my SAT scores were back in the 1970's was not a place that I was interested in going. (assuming I could remember what they were!)