I usually try to keep mine down to about 20-25 a lecture on average to make it more manageable. I basically do exactly what you do, just with less cards. I will admit that it is very time consuming and some weeks I fall behind on Anki. With Anki, I basically only make a card if it is both something that is high-yield and requires memorization of facts (such as micro and pharm). So for some lectures I don't make very many cards and for others (such as pharm) I may make as many as 35-40, but the average is around 20.