Hrt

[apara]

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All of the following statements about HRT (hormone replacement therapy) are true except
1. It increases the risk of coronary artery disease
2. It increases bone mineral density
3. It increases the risk of breast cancer
4. It increases the risk of Endometrial cancer

 

[Janders]

All of the following statements about HRT (hormone replacement therapy) are true except
1. It increases the risk of coronary artery disease
2. It increases bone mineral density
3. It increases the risk of breast cancer
4. It increases the risk of Endometrial cancer

1?

 

[smgilles]

All of the following statements about HRT (hormone replacement therapy) are true except
1. It increases the risk of coronary artery disease
2. It increases bone mineral density
3. It increases the risk of breast cancer
4. It increases the risk of Endometrial cancer

1.

 

[HamOnWholeWheat]

1.

Am I missing something? Its either 3 or 4, depending on the formulation, right? Estrogen increases both, progresterone decreases endometrial. Both increase risk of CAD. Or am I remembering that wrong from Path, Parm, and Clinicals?

Back me up someone,

HamOn

 

[ziffy 850]

depends on material you read. used to be believed that it decreased chances of coronary artery disease, but recently found to increase it within first few year-i go for 4

 

[Pox in a box]

THe estrogen is what increases your CAD risks. I think it's 2. The estrogen decreases the action of the osteoclasts. It has no effect on how much bone gets laid down.

 

[RLMD]

2, definitely.

 

[smgilles]

Am I missing something? Its either 3 or 4, depending on the formulation, right? Estrogen increases both, progresterone decreases endometrial. Both increase risk of CAD. Or am I remembering that wrong from Path, Parm, and Clinicals?

Back me up someone,

HamOn

HRT therapy w/unopposed estrogen definitely increases chances of 3 and 4, but I guess I always thought that the benefit of HRT was it decreased ischemic heart disease and osteoporosis. That's why I didn't think it could be 2, 3, or 4.

Isn't that one of the hypothesis as why pre-menopausal women have lower rates of CAD than men, because of the beneficial effects of estrogen? In the broad sense here.

 

[ziffy 850]

HRT therapy w/unopposed estrogen definitely increases chances of 3 and 4, but I guess I always thought that the benefit of HRT was it decreased ischemic heart disease and osteoporosis. That's why I didn't think it could be 2, 3, or 4.

Isn't that one of the hypothesis as why pre-menopausal women have lower rates of CAD than men, because of the beneficial effects of estrogen? In the broad sense here.

Wish we could get an answer on this. I really have to go with doesn't increase bone density unless someone can tell me that it does. New study takes many women off hrt because of recent findings that it increases chances of heart disease-unopposed estrogen definitely increases chances of 3 and 4-sooooo it just leaves 2 (it may decrease chances of osteoporosis, but does it INCREASE bone density>

 

[idq1i]

All of the following statements about HRT (hormone replacement therapy) are true except
1. It increases the risk of coronary artery disease
2. It increases bone mineral density
3. It increases the risk of breast cancer
4. It increases the risk of Endometrial cancer

1 = still being debated/depends on the population/hypercoagulability more likely
2 = depends on what the q writer had in mind. Estrogens/SERMs downregulate osteoclast activity/reduce IL-6, but they do not (afaik) activate osteoblasts
3 = true
4 = sure does

 

[pillowhead]

Wish we could get an answer on this. I really have to go with doesn't increase bone density unless someone can tell me that it does. New study takes many women off hrt because of recent findings that it increases chances of heart disease-unopposed estrogen definitely increases chances of 3 and 4-sooooo it just leaves 2 (it may decrease chances of osteoporosis, but does it INCREASE bone density>

this is just from class, but we've definitely had lecturers say that there are only two reasons to give HRT now. Symptomatic relief of menopause (like hot flashes) and osteoperosis. whether or not it increases BMD or just prevents further loss, I'm not sure.

I'd like to know when this question was written because if it's a few years old, then #1 would be the correct answer when we thought HRT reduced CAD risk. Otherwise, by today's standards, I don't think there's a right answer.

at any rate, this isn't a board type question because they don't ask except-type questions. so that's good news i guess.

 

[HiddenTruth]

at any rate, this isn't a board type question because they don't ask except-type questions. so that's good news i guess.

The concept and principle certainly is.

 

[4424]

The concept and principle certainly is.

i agree w/ #2. from my understanding estrogen is not used to TREAT bone loss, only to prevent it. Pox in a box's explanation is correct from what I have learned

 

[bigfrank]

All of the following statements about HRT (hormone replacement therapy) are true except
1. It increases the risk of coronary artery disease
2. It increases bone mineral density
3. It increases the risk of breast cancer
4. It increases the risk of Endometrial cancer

This is a bad question, for a variety of reasons. 1) You will not get a question about this controversial topic and 2) don't study from "EXCEPT" types of questions.

😉

 

[HamOnWholeWheat]

1 = still being debated/depends on the population/hypercoagulability more likely
2 = depends on what the q writer had in mind. Estrogens/SERMs downregulate osteoclast activity/reduce IL-6, but they do not (afaik) activate osteoblasts
3 = true
4 = sure does

I have to disagree with this on a logical basis (which doesn't mean jack in the world of the USMLE).

I agree with your explanation of #1.

#2: it could be the question is saying it increases BMD "compared to a pt. not receiving HRT". Its never clarified.

#3 + #4: HRT doesn't increase the risk of endometrial cancer, Estrogen does. But to put a pt. with a uterus on pure estrogen hrt is not going to happen unless its Dr. Nick Riviera. HRT is almost always a Estrogen/Progesterone mixture, which has been shown to DECREASE endometrial cancer but INCREASE breast cancer (even moreso than straight estrogen HRT). So 3 and 4 can't both be true unless it specifies ERT, and not HRT.

Crappy question, but good debate fodder.

HamOn