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Hey,
So in Huntington's, if you have loss of GABAergic neurons in the neostriatum, then why do you have a net increase in movements with chorea?
In the direct pathway: if you have decreased release of GABA from the striatum -> decreased inhibition of the Globus Pallidus Internal -> increased inhibition of Thalamus -> decreased movements
In the indirect pathway: if you have decreased release of GABA from the striatum -> decreased inhibition of the Globus Pallidus External -> increased inhibition of Subthalamic Nucleus -> decreased excitation of Globus Pallidus Internal -> decreased inhibiton of Thalamus -> increased movements
So how is the net result increased movements when you lose GABA from the striatum?
So in Huntington's, if you have loss of GABAergic neurons in the neostriatum, then why do you have a net increase in movements with chorea?
In the direct pathway: if you have decreased release of GABA from the striatum -> decreased inhibition of the Globus Pallidus Internal -> increased inhibition of Thalamus -> decreased movements
In the indirect pathway: if you have decreased release of GABA from the striatum -> decreased inhibition of the Globus Pallidus External -> increased inhibition of Subthalamic Nucleus -> decreased excitation of Globus Pallidus Internal -> decreased inhibiton of Thalamus -> increased movements
So how is the net result increased movements when you lose GABA from the striatum?
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