Aug 2, 2014
151
54
Hey,
So in Huntington's, if you have loss of GABAergic neurons in the neostriatum, then why do you have a net increase in movements with chorea?

In the direct pathway: if you have decreased release of GABA from the striatum -> decreased inhibition of the Globus Pallidus Internal -> increased inhibition of Thalamus -> decreased movements

In the indirect pathway: if you have decreased release of GABA from the striatum -> decreased inhibition of the Globus Pallidus External -> increased inhibition of Subthalamic Nucleus -> decreased excitation of Globus Pallidus Internal -> decreased inhibiton of Thalamus -> increased movements

So how is the net result increased movements when you lose GABA from the striatum?
 
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