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Step I hydroxiurea
Started by usmletoo
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Hey,
Erm, they don't really know HOW it increases HbF, is the thing. HU works by inhibiting the enzyme ribonucleotide reductase, but exactly how this increases HbF is not well understood, plus they won't ask you about that on the USMLE. Just know the thing about ribonucleotide reductase and make sure you really understand why more HbF is a big big good.
[SCA is basically a beta-chain defect. HbF is alpha-2/gamma-2 (ie no beta) and has a higher affinity to oxygen]
good luck!
Erm, they don't really know HOW it increases HbF, is the thing. HU works by inhibiting the enzyme ribonucleotide reductase, but exactly how this increases HbF is not well understood, plus they won't ask you about that on the USMLE. Just know the thing about ribonucleotide reductase and make sure you really understand why more HbF is a big big good.
[SCA is basically a beta-chain defect. HbF is alpha-2/gamma-2 (ie no beta) and has a higher affinity to oxygen]
good luck!
