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Step I hyperthyroidism
Started by faisal 2000
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Increased synthesis of β1-receptors accounts for the tachycardia.
Like AnalisCanalis said, Inc. synthesis , and expression of β1-receptors on SA and AV node -> Tachycardia.
Note: In Thyroid Storm -> surge of Catecholamines, which bind to these β1-receptors -> Tachyarrythmias -> Cardiac Failure -> Death.
Note: In Thyroid Storm -> surge of Catecholamines, which bind to these β1-receptors -> Tachyarrythmias -> Cardiac Failure -> Death.
Not that this is a major point, but I have a feeling there isn't a surge of catecholamines, per se. I believe, as correctly stated here, there is an up-regulation of beta-1 receptor transcription, serving to enhance the body's sensitivity to already circulating TH. But I could be wrong. But thank goodness esoteric details like this don't matter on the exam. Sometimes.
