Hypocalcemia in pancreatitis

[Kenji]

Why does the pancreatitis cause hypocalcemia ?

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[XRanger]

fat necrosis causes release of free fatty acids which bind to calcium -> leads to calcium precipitation

 

[Kenji]

Sorry could you explain me more how the free fatty acid bind with calcium lead to hypocalcemia(mechanism)?or do you have the referent?

 

[Thanatopsis]

Pancreatitis causes a release of pancreatic enzymes into circulation. The enzymes damage the walls of blood vessels causing interstitial leakage, allowing more of their kind to begin to wreak extravascular havoc. Among many others, fat cells are damaged.

The enzymatic cocktail contains lipase. Lipase normally digests triglycerides to free fatty acids beginning in the duodenum to facilitate micelle formation and fatty acid absorption. In the extravascular environment, damaged fat cells provide the trigs. These free fatty acids have an exposed carboxyl group. In their basic form there is a -1 charge shared between the two oxygens. Ca (+2) likes this and will bind it. In this way, the level of hypocalcemia can aid in determining the extent of the enzymatic damage and/or level of pancreatitis.

 

[BigRedder]

Imagine you have a solution with calcium dissolved in it. You then add something that binds to calcium (in this case fatty acids), and the calcium precipitates. The concentration goes down.

Google has some answers...

 

[Kenji]

Thank all of you guy

 

[Kenji]

Oh is it possible that pancreatitis cause hyperamylasemia. And this enzyme affect to parathyroid gland that lead to hypocalcemia.

 

[Kenji]

How does the alcohol cause chronic pancreatitis?

 

[Laryngophed]

http://tinyurl.com/2uo9xwl

I'm all for helping folks out but sheesh, pick up a book first.

 

[njbmd]

Homework Help and now closing. Any of these questions can be answered by opening a pathology book or Google.