I've been thinking a lot about this too lately (it's that time of year!) and here's my take on it for what it's worth... Region is big for me - I want to stay close to my family so that narrows it down quite a bit. Obviously I will apply to my undergrad and my in-state schools. From there I just looked through the MSAR for schools in the Midwest that roughly matched my stats. Also ask around at your university and see where students from your school have had good luck... I've found that a lot of people from my school seem to go to other Jesuit schools for med school - maybe there is a similar trend at your school. I'm probably applying to too many schools, but hopefully I'll only apply once, so I might as well have plenty of options. Hope that helped somewhat! Good luck