The earlier, the better! E-submit now because you'll have to play the waiting game for other things in the meantime like verification, letters, transcripts, etc. if those haven't been sent yet. Don't lose hope because there have been people who e-submitted later (September, October) and have gotten interviews (I browsed the "Late applicants support club" thread recently just because I was curious--you should give it a look and maybe it'll ease your mind). Submit now.