I wish I could pronounce the enzyme names in Heme synthesis

[PokerDoc]

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then maybe I would have an easier time getting those questions right haha... is it just me or does this pathway get you guys more often than any other biochemical pathway?

 

[match2011]

where can I get an online medical dictionary with pronunciation?

Thanks

 

[badasshairday]

Did you notice that porphobilogen deaminase has two other names? So lame.

 

[PokerDoc]

Did you notice that porphobilogen deaminase has two other names? So lame.

exactly the question on UW i was looking at when I made this post.. so annoying.. I didnt even know what they were talking about

 

[xanthomondo]

Try using abbrevations.

I also only remember the relative position of intermediates in which there is a disease/problem and what intermediates will accumulate.

Pb poisoning - first (after the committed step) and last reactions are inhibited. These enzymes are something having ALA in its name and something having ferro in its name. You know its not ALA synthase that's inhibited because you will get an ALA accumulation, so the enzyme is ALA dehydratase. Ferro has a metal's name in it already so that shouldn't be hard to connect.

AIP - you get a backup of PB (so much peanut butter in your stomach it hurts). Peanut butter deaminse is the enzyme. If they refer to the other enzyme name just think that you're going to have to make U.P. for later down the road. UP synthase.

Porpheria cutanea tarda - you get a backup of UP (you pee on my skin). You pee decarboxylase is at fault.

Sorry if it doesn't help lol

 

[xanthomondo]

Did you notice that porphobilogen deaminase has two other names? So lame.

exactly the question on UW i was looking at when I made this post.. so annoying.. I didnt even know what they were talking about

Yeah, and the most annoying thing in FA is that on the page they mention both ezymes very passively. AIP is a defect in this enzyme in the chart, but it mentions another enzyme in the diagram.

 

[PokerDoc]

Try using abbrevations.

I also only remember the relative position of intermediates in which there is a disease/problem and what intermediates will accumulate.

Pb poisoning - first (after the committed step) and last reactions are inhibited. These enzymes are something having ALA in its name and something having ferro in its name. You know its not ALA synthase that's inhibited because you will get an ALA accumulation, so the enzyme is ALA dehydratase. Ferro has a metal's name in it already so that shouldn't be hard to connect.

AIP - you get a backup of PB (so much peanut butter in your stomach it hurts). Peanut butter deaminse is the enzyme. If they refer to the other enzyme name just think that you're going to have to make U.P. for later down the road. UP synthase.

Porpheria cutanea tarda - you get a backup of UP (you pee on my skin). You pee decarboxylase is at fault.

Sorry if it doesn't help lol

hahaha this is awesome, thanks!

 

[mq123]

FWIW: I always avoided really studying the pathway because I just could never make it stick, until I got question after question wrong on UW. So, I went back to look over it, and realized there are only 2 main 'porphyrias' (AIP and PCT) associated with the 7 or 8-step pathway. I just memorized them similarly to what the poster above suggested... 👍

 

[aashkab]

PokerDoc, we are going to look like complete TOOLS next year on our rotations, lol.

I was saying "chelators" earlier to myself but i was saying it like the country, Chile...It got way too spanish real fast