idiotope vs paratope and Epitope vs Hapten...Hapten relation to drug allergy

[learnconcepts]

Hello everyone

Hello all...I have confusion between IDIOTOPE & PARATOPE
I have idea of epitope which is binding part of antigen

BUT kaplan says if epitope of LMW and which binds with only 1 Bcell ereceptor will not behave as epitope and it is considered HAPTEN

I got drug allergy concept with HAPTEN-carrier conjugate(immunogen)..Hapten relation to drug allergy...plz explain this with examples

But plz explain in simple way idiotope vs paratope and Epitope/Hapten...confusing here a lot...

Everyone plz participate in this concept...am confused...its good to share ideas on this concept which is not quite common to all

thanks in advance

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[learnconcepts]

plz help me with above concept...they are confusing me a lot...especially Bcell receptors binding to antigen...B-cell have 2 immunoglobulins and each have 2 FAB segments..my doubt is wheteher how many antigens bind Bcell and Bcell receptors(Bcell have 2 immunoglobulins/BCR)...totally confused

 

[bbydoc]

Hello everyone

Hello all...I have confusion between IDIOTOPE & PARATOPE
I have idea of epitope which is binding part of antigen

BUT kaplan says if epitope of LMW and which binds with only 1 Bcell ereceptor will not behave as epitope and it is considered HAPTEN

I got drug allergy concept with HAPTEN-carrier conjugate(immunogen)..Hapten relation to drug allergy...plz explain this with examples

But plz explain in simple way idiotope vs paratope and Epitope/Hapten...confusing here a lot...

Everyone plz participate in this concept...am confused...its good to share ideas on this concept which is not quite common to all

thanks in advance

A paratope is a specific part of the Antigent-binding site on an Immunoglobulin, this part binds to an epitope.
An epitope is those parts on an antigen, which can be recognized by the paratope.
1 Immunoglobulin has 2 Antigen-binding sites on the Fab region, each one of these Antigen-binding sites can bind to several points on 1 antigen, these points are called epitopes.
A monomeric (1 monomer) Immunoglobulin like IgG can bind 2 Antigens while a secreted IgA can bind 4 antigens in its dimeric form and 2 Antigens in its monomeric form circulating in your blood stream.

If IgM binds an Antigen on 2-3 epitopes (2-3 points on the same antigen) it displays less affinity than the binding of the same antigen to the Antigen-binding site of an IgG where the Antigen-binding site binds to more than 3 epitopes on the same antigen.


A B cell receptor consists of 2 parts, it is basically an IgM or IgD bound to the cell-surface of a B-cell + a signal-transduction complex.

 

[learnconcepts]

A paratope is a specific part of the Antigent-binding site on an Immunoglobulin, this part binds to an epitope.
An epitope is those parts on an antigen, which can be recognized by the paratope.
1 Immunoglobulin has 2 Antigen-binding sites on the Fab region, each one of these Antigen-binding sites can bind to several points on 1 antigen, these points are called epitopes.
A monomeric (1 monomer) Immunoglobulin like IgG can bind 2 Antigens while a secreted IgA can bind 4 antigens in its dimeric form and 2 Antigens in its monomeric form circulating in your blood stream.

If IgM binds an Antigen on 2-3 epitopes (2-3 points on the same antigen) it displays less affinity than the binding of the same antigen to the Antigen-binding site of an IgG where the Antigen-binding site binds to more than 3 epitopes on the same antigen.


A B cell receptor consists of 2 parts, it is basically an IgM or IgD bound to the cell-surface of a B-cell + a signal-transduction complex.

Thank u
But one doubt..B cell receptor can have either igM or igD...its ok..but my question now is as follows..suppose Bcell have igM and we know igM have 2Fab regions...so it means 2 antigens binds to 2 Fab regions of igM..i mean 1 antigen to 1Fab and other antigen at other Fab of same igM...hope u got me