I mean why not the leading strand? It has the RNA primer to start with at the very beginning of replication.
Is it just the lagging strand that have end replication problem?
- Thread starter redPastel
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2 minutes for perfect visual explanation.
Very short version...
The leading strand does not have end replication problems because it's replicated 5>3 and goes all the way to the end of the chromosome.
On the opposite end of the chromosome the same problem occurs but on the other strand (still the lagging strand but the DNA polymerase is going in the opposite direction...)
Basically the problem is always on the lagging strand... But on one end it is the coding strand and on the other end it's the template strand.
(Remember, DNA replication is bi-directional, so the lagging strands are different depending on what direction you are going)
Hope that helps, videos are probably better at explaining it.
Very short version...
The leading strand does not have end replication problems because it's replicated 5>3 and goes all the way to the end of the chromosome.
On the opposite end of the chromosome the same problem occurs but on the other strand (still the lagging strand but the DNA polymerase is going in the opposite direction...)
Basically the problem is always on the lagging strand... But on one end it is the coding strand and on the other end it's the template strand.
(Remember, DNA replication is bi-directional, so the lagging strands are different depending on what direction you are going)
Hope that helps, videos are probably better at explaining it.
