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Is it possible for gluconeogenesis take place in the mitochondria?

Discussion in 'MCAT Study Question Q&A' started by Gauss44, Sep 7, 2014.

  1. Gauss44

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    Is it possible for gluconeogenesis take place in the mitochondria?

    (I know it can take place in the cytoplasm, but what about in the mitochondria?)
     
  2. Cawolf

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    There are many steps in the pathway, and some of them can take place within the mitochondria - such as the production of oxaloacetate.

    However, the final step utilizes glucose-6-phosphatase to go from glucose-6-phosphate ----> glucose + pi

    (the opposite of gluco/hexo-kinase)

    This enzyme is mainly (minor exceptions such as parts of kidney) in the liver (attached to the ER).
     
    Gauss44 likes this.

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