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Is it possible for gluconeogenesis take place in the mitochondria?

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Gauss44

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Is it possible for gluconeogenesis take place in the mitochondria?

(I know it can take place in the cytoplasm, but what about in the mitochondria?)
 

Cawolf

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There are many steps in the pathway, and some of them can take place within the mitochondria - such as the production of oxaloacetate.

However, the final step utilizes glucose-6-phosphatase to go from glucose-6-phosphate ----> glucose + pi

(the opposite of gluco/hexo-kinase)

This enzyme is mainly (minor exceptions such as parts of kidney) in the liver (attached to the ER).
 
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