Goljan states that ischemic ATN most commonly results in permanent damage because the tubular basement membranes are disrupted during the ischemic episode, where as nephrotoxic ATN usually results in tubular epithelial regeneration because the basement membranes tend to stay intact. Question on UW is a guy in a car accident, heavy bleeding leads to oliguria (ischemic ATN) what is the most likely outcome? The answer says tubular re-epithelialization because that is the most common outcome as long as multi organ failure is not present. Not sure that it is a high likelihood to show up on the real test, but since it seems to be a direct discrepancy, what do you guys think? Goljan doesn't seem to make a distinction between the severity of the ischemic ATN as far as whether multi organ failure is involved, so perhaps that is key.