ISn't proline a major contributor to beta-sheets

[inaccensa]

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I know I read that somewhere. It is a helix breaker but is used in beta turns?

 

[Bumbl3b33]

I know I read that somewhere. It is a helix breaker but is used in beta turns?

proline just causes turns due to steric reasons, in any 2ndary structure (a-helix and B-sheets); everything else would have to depend on interactions with other R-groups

 

[salim271]

It doesnt show up in helices because its too bulky but its a major component in beta turns usually accompanied by gly and i believe ser and thr but dont quote me on the last two.

 

[imapremed]

I know I read that somewhere. It is a helix breaker but is used in beta turns?

i believe you are referring to beta turns as in it causes beta helixes and not teh NORMAL alpha helixes that is all i think its just a term to refer to the abnormal condition...

 

[SN2ed]

Thread moved. This type of question belongs in the MCAT Study Q&A.

 

[inaccensa]

So if the q is asking whether it contributes to secondary structure of a protein, the correct ans is "no" ?

 

[docntrainin]

EK says that proline interrupts alpha helix formation. I read online (NCBI study) that "Proline is established as a potent breaker of both alpha-helical and beta-sheet structures in soluble (globular) proteins."