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Isoproterenol

dragon529

MS-III
10+ Year Member
Jul 25, 2007
715
2
201
Los Angeles, CA
  1. Medical Student
Isoproternol only affects B1 and B2. Through B1, it increases heart rate and through B2 it vasodilates. The vasodilation cause drop in blood pressure.

Compare with norepinephrine which affects alpha 1,2 and beta 1 so it vasoconstricts via alpha1 and there's a reflex decrease in heart rate because of that.

I know you took this from FA and that little paragraph underneath sums it up.
 

Ycut

Full Member
Oct 20, 2012
101
1
1
  1. Non-Student
Isoproternol only affects B1 and B2. Through B1, it increases heart rate and through B2 it vasodilates. The vasodilation cause drop in blood pressure.

Compare with norepinephrine which affects alpha 1,2 and beta 1 so it vasoconstricts via alpha1 and there's a reflex decrease in heart rate because of that.

I know you took this from FA and that little paragraph underneath sums it up.

B2 stimulation-Vasodilation-decreases (TPR) and as a result diastolic BP
B1 stimulation-positive inotropism+ chronotropism-which must increase (Stroke volume) and as a result systolic BP
 
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dragon529

MS-III
10+ Year Member
Jul 25, 2007
715
2
201
Los Angeles, CA
  1. Medical Student
If you inject isoproternol, BP has to decrease for 2 reasons. Through beta1, you pump the heart stronger and faster then you'll get reflex vasodilation. Also, through beta2, it vasodilates because that's what it does.

You have to think about the reflex the drug is indirectly causing because our body is constantly trying to maintain homeostasis.
 
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