Isovue-M

[epidural man]

What is the difference between ISOVUE-M and ISOVUE, other than one says you can use intrathecally, and the other says you can't?

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[pastafan]

https://cdn.ymaws.com/www.spineintervention.org/resource/resmgr/factfinder/Contrast_Medium_FF_11-18-201.pdf

 

[epidural man]

https://cdn.ymaws.com/www.spineintervention.org/resource/resmgr/factfinder/Contrast_Medium_FF_11-18-201.pdf

Maybe I am a dummy - but I cant find in this PDF where it explains the difference. Can you help me? This is the PDF that made me ask the question in the first place.

 

[jqueb29]

There is not any difference in ingredients. The only difference is that Isovue-M comes in smaller bottles (supposed to be a safety mechanism since obv the max amount of Isovue intrathecally is less than other areas) and has undergone specific FDA approval for intrathecal use. But in terms of what the product actually is, they are 100% the same.

 

[pastafan]

Contrast Medium FactFinder
Committed to providing helpful information to International Spine Intervention Society members about key patient safety issues, the Society’s Patient Safety Committee has developed a FactFinder series. FactFinders will explore and debunk myths surrounding patient safety issues. The intent of this FactFinder is to clarify the different indications for use of different formulations of contrast medium and the reported adverse effects related to each.
Myth #1: Isovue and Isovue-M have the same indications.
Fact: The indications for Isovue and Isovue-M overlap, but are still unique. Isovue is not indicated for intrathecal use, while Isovue-M is specifically indicated for intrathecal use.
When contrast medium is used for spinal injections, intrathecal injection of contrast or steroids is not expected. As articulated in the International Spine Intervention Society’s FactFinder on Preservatives,1 if the needle tip is properly placed, intrathecal injection of contrast medium is unlikely and therefore the choice of Isovue or Isovue-M is inconsequential.
For intrathecal pumps and intrathecal neurolysis, or when inadvertent intrathecal injection of contrast medium is a concern, the correct choice of contrast medium is necessary. The different indications for Isovue and Isovue-M are clearly defined in the package inserts.
Isovue
Isovue is not indicated for intrathecal injection and the indications are clearly defined on the package insert.2
Published November 2013

If used in the nervous system there is a clear risk of adverse reactions including pain (2.8%) and burning sensation (1.4%).2
Isovue-M
In contrast, Isovue-M is specifically indicated for intrathecal injection, which is clearly defined as an indication on the package insert.3
There have been no central nervous system adverse reactions with an incidence greater than 1% when Isovue-M was injected.3
Summary
 Both Isovue and Isovue-M can be used for non-intrathecal pain injections.
 Although Isovue-M is indicated for intrathecal injection, it is not completely
safe. There is a case report of malignant cerebral edema after intrathecal injection of Isovue-M.4 As with all medications and injections, the risks and benefits need to be fully evaluated with the patient prior to use.
 If an intrathecal injection is planned, or inadvertant intrathecal injection is a concern, Isovue is not the contrast agent of choice.
Published November 2013

Myth #2: Omnipaque 350 and Omnipaque 300 have the same indications.
Fact: The indications for Omnipaque 300 and Omnipaque 350 overlap, but are still unique. Omnipaque 350 is not indicated for intrathecal use, while Omnipaque 300 is specifically indicated for intrathecal use.
The different indications for Omnipaque 300 and Omnipaque 350 are clearly defined on the packaging and in the package inserts.
Omnipaque 350
Omnipaque 350 is not indicated for intrathecal injection, and the indications are clearly defined in the package insert.5
Published November 2013
Omnipaque 300
In contrast, Omnipaque 300 is specifically indicated for intrathecal injection, which is clearly indicated on the package insert.5

Published November 2013
There have been no central nervous system adverse reactions with an incidence greater than 1% when Omnipaque 300 was injected.5
Summary
 Both Omnipaque 300 and Omnipaque 350 can be used for non-intrathecal pain injections.
 Although Omnipaque 300 is indicated for intrathecal injection, it is not completely safe. There is a case report of aseptic meningoencephalitis after intrathecal injection of Omnipaque 300.6 As with all medications and injections, the risks and benefits need to be fully evaluated with the patient prior to use.
 If an intrathecal injection is planned, or inadvertant intrathecal injection is a concern, Omnipaque 350 is not the contrast agent of choice.
References:
1. International Spine Intervention Society FactFinder: Preservative vs. Preservative-Free: Steroid Choice for Epidural Steroid Injections. September 2013. http://1515docs.org/factfinders/Preservative-Free_ESI_9-10-2013.pdf
2. http://imaging.bracco.com/sites/braccoimaging.com/files/technica_sheet_pdf/I SOVUE200-370-8.5x11_0.pdf
3. Kelley BC, Roh S, Johnson PL, Arnold PM. Malignant Cerebral Edema following CT Myelogram Using Isovue-M 300 Intrathecal Nonionic Water-Soluble Contrast: A Case Report. Radiol Res Pract. Epub 2011 Jan 13.
4. Omnipaque (GE Healthcare): FDA Package Insert

5. Romesburg J, Ragozzino M. Aseptic meningoencephalitis after iohexol CT myelography. AJNR Am J Neuroradiol. 2009 May;30(5):1074-1075.
Published November 2013

 

[pastafan]

I always thought only the label differed but side effects incidence differs.

 

[Orin]

I assume there are some higher quality controls and tests run on the Isovue-M. I don't see any clear differences otherwise but I expect that stricter tolerance/QC is part of the reason there may be less risk with it in the more sensitive space.

 

[PinchandBurn]

So confused. They say isovue M and omnipaqu 300 are better. However they both are associated with cerebral edema etc..

Sounds like you can use either. Also I wonde rif this is dose dependent side effects. I never use more than 1ml Contrast usually...

 

[lobelsteve]

Just use Ominpaque 240, never have to worry.

 

[geauxg8rs]

Just use Ominpaque 240, never have to worry.

View attachment 360201

I wouldn’t flash that stash. I am actually laying over in ATL and thinking of going on a raid

 

[lobelsteve]

I wouldn’t flash that stash. I am actually laying over in ATL and thinking of going on a raid

Locked room. And that is a safe.
Bribe me. Carrot cake? Zingermans?

 

[Ducttape]

Bribe me. Carrot cake? Zingermans?

not sure how that would be a fair trade.

there is only 1 Zingermans...