Kidney question

[Phloston]

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If a kidney is removed, what happens to the filtered load of creatinine, and why?

Please be specific, and what is the mechanism?

 

[Belleza156]

All I can say is I did a question somewhere that said that if a kidney is removed, than the other kidney will pick up the slack. But that ultimately you can never have 100% function, you will have 80% tops.

 

[Phloston]

All I can say is I did a question somewhere that said that if a kidney is removed, than the other kidney will pick up the slack. But that ultimately you can never have 100% function, you will have 80% tops.

So what answer are you arriving at / reasoning toward?

Btw, thanks for being the only one to respond to my posts. But yeah, it's the early-AM on Wednesday here in Australia, so I'll try and get back to you in several hours after I awaken. You have plenty of time to think.

 

[Belleza156]

Here is one of the times where what seems like the most logical scenario is not what happens. I would have thought that creatinine would increase due to decreased GFR, but Ehhhh! Wrong!

According to Best Practice-BMJ:

"Physiological adaptation

Serum creatinine levels increase after kidney donation or after unilateral or partial nephrectomy. After an initial rise, serum creatinine decreases due to hyperfiltration by the remaining nephrons and reaches a new steady state. In the long term, serum creatinine remains at 141 to 159 micromol/L (1.6 to 1.8 mg/dL) in patients who have a normal contralateral kidney. Any sustained rise in serum creatinine above the normal range requires further investigation."

Apparently when the remaining kidney picks up the slack and hypertrophies, it ends up hyperfiltrating. So that eventually there is even less serum creatinine (increased filtered load) than before the nephrectomy.

 

[Phloston]

Here is one of the times where what seems like the most logical scenario is not what happens. I would have thought that creatinine would increase due to decreased GFR, but Ehhhh! Wrong!

According to Best Practice-BMJ:

"Physiological adaptation

Serum creatinine levels increase after kidney donation or after unilateral or partial nephrectomy. After an initial rise, serum creatinine decreases due to hyperfiltration by the remaining nephrons and reaches a new steady state. In the long term, serum creatinine remains at 141 to 159 micromol/L (1.6 to 1.8 mg/dL) in patients who have a normal contralateral kidney. Any sustained rise in serum creatinine above the normal range requires further investigation."

Apparently when the remaining kidney picks up the slack and hypertrophies, it ends up hyperfiltrating. So that eventually there is even less serum creatinine (increased filtered load) than before the nephrectomy.

Interesting. I have annotated into my FA that creatinine levels rise, but filtered load remains the same. I like the info you've provided though, as that clears things up a little now.