free99 Full Member Moderator Emeritus Verified Member 10+ Year Member Dentist Verified Expert Joined Oct 24, 2012 Messages 1,937 Reaction score 990 Feb 11, 2013 #1 Members don't see this ad. Does KOtBu always create the hoffman product or is there a situation in which the Zaitsev product is favored?
Members don't see this ad. Does KOtBu always create the hoffman product or is there a situation in which the Zaitsev product is favored?
I IsaacYankem Full Member 10+ Year Member Joined Feb 25, 2012 Messages 508 Reaction score 111 Feb 11, 2013 #2 Yes. It's a bulky base and goes Hoffman, while also selectively preferring E2 over SN2. Upvote 0 Downvote
D DenTony11235 Feb 12, 2013 #3 free99 said: Does KOtBu always create the hoffman product or is there a situation in which the Zaitsev product is favored? Click to expand... KOtBu is potassium Tert-Butyl. the Tert-butyl is as bulky as it gets man, its huge! so it attacks the least hindered, least substituted side best because it can't dig deeper in. Upvote 0 Downvote
free99 said: Does KOtBu always create the hoffman product or is there a situation in which the Zaitsev product is favored? Click to expand... KOtBu is potassium Tert-Butyl. the Tert-butyl is as bulky as it gets man, its huge! so it attacks the least hindered, least substituted side best because it can't dig deeper in.
