LAP levels in CML and AML

[cheruka]

Why does LAP level go down in CML and AML?
Thanks!

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[ASAPRocky]

who cares, just know it does to distinguish it from leukemoid reaction or whatever it is called.

 

[MrBeauregard]

^^^ I love this guy.

 

[zstranger2]

Why does LAP level go down in CML and AML?
Thanks!

According to Conrad Fischer: alkaline phosphatase is made by normal neutrophils. In CML, PNH and hypophosphatemia, there is high but abnormal neutrophils that are not producing alkaline phosphatase.

 

[cheruka]

According to Conrad Fischer: alkaline phosphatase is made by normal neutrophils. In CML, PNH and hypophosphatemia, there is high but abnormal neutrophils that are not producing alkaline phosphatase.

Thanks!
I love it when people can tell me the "why",🙂