Lecturio wrong questions?

[Patrick Bateman's Brother]

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So I have a Lecturio subscription, and I noticed that two questions appeared to be wrong. Wrote to their support system and was told the answers were correct and were vetted by their medical experts. I attached both pictures. My answers are marked in red. The correct ones are marked in green.

Am I not seeing something, or are these questions wrong?

 

[Goro]

Lecturio questions are poor, to say the least.

 

[getfat]

Lecturio questions are poor, to say the least.

Are you referring to these questions or lecturio in general (Qbanks included)

The post-video questions are very simple but I like them to help retain material. Goes over what you immediately covered to make sure you have it down.

 

[BorntobeDO?]

check mark is correct on first one. increased plasma binding would decrease the VD. Since VD is the amount of drug in the tissue (see "The VD of a drug represents the degree to which a drug is distributed in body tissue rather than the plasma." Volume of distribution - Wikipedia ). By definition having more plasma binding would result in less VD.


In the second one the answer with an X contains an error (i.e. why its wrong), host cells with the virus would not display MHC I, thats why the NK cells initiating cell death. "As an evolutionary response to this method of immune surveillance, many viruses are able to down-regulate or otherwise prevent the presentation of MHC class I molecules on the cell surface. In contrast to cytotoxic T lymphocytes, natural killer (NK) cells are normally inactivated upon recognizing MHC I molecules on the surface of cells. Therefore, in the absence of MHC I molecules, NK cells are activated and recognize the cell as aberrant, suggesting that it may be infected by viruses attempting to evade immune destruction." MHC class I - Wikipedia

I could see how this could confuse you d/t MHC1 normally presenting antigens, but virus will down-regulate it in order to hide themselves. So to an NK cell, normal would be having anything present on MHCI rather than nothing there at all.

 

[Goro]

Are you referring to these questions or lecturio in general (Qbanks included)

The post-video questions are very simple but I like them to help retain material. Goes over what you immediately covered to make sure you have it down.

The post lecture questions AND the item bank.

I've seen items with no correct answer, and multiple correct answers.

 

[Patrick Bateman's Brother]

check mark is correct on first one. increased plasma binding would decrease the VD. Since VD is the amount of drug in the tissue (see "The VD of a drug represents the degree to which a drug is distributed in body tissue rather than the plasma." Volume of distribution - Wikipedia ). By definition having more plasma binding would result in less VD.


In the second one the answer with an X contains an error (i.e. why its wrong), host cells with the virus would not display MHC I, thats why the NK cells initiating cell death. "As an evolutionary response to this method of immune surveillance, many viruses are able to down-regulate or otherwise prevent the presentation of MHC class I molecules on the cell surface. In contrast to cytotoxic T lymphocytes, natural killer (NK) cells are normally inactivated upon recognizing MHC I molecules on the surface of cells. Therefore, in the absence of MHC I molecules, NK cells are activated and recognize the cell as aberrant, suggesting that it may be infected by viruses attempting to evade immune destruction." MHC class I - Wikipedia

I could see how this could confuse you d/t MHC1 normally presenting antigens, but virus will down-regulate it in order to hide themselves. So to an NK cell, normal would be having anything present on MHCI rather than nothing there at all.

Thank you. This was throwing me for quite a loop.

 

[BorntobeDO?]

Thank you. This was throwing me for quite a loop.

NP, it happens to the best of us.