It is absolutely appropriate ... and yes, the sooner the better. You need to be proactive about getting off the waitlist -- otherwise you'll languish there until all places are filled. Check out the waitlist chat on Accepted.com at <a href="http://www.accepted.com/chat/transcripts/2002/mba03112002.aspx" target="_blank">http://www.accepted.com/chat/transcripts/2002/mba03112002.aspx</a> -- a lot of it's directed toward business school, but there are some med school applicants involved, and the general strategy to get off a waitlist is very much the same.